服務熱線
13817140470
產品介紹
Description
Application Used to select animal cells expressing the Escherichia coli gene for xanthine-guanine phosphosribosyl transferase.
Biochem/physiol Actions Mode of Action: Blocks inosine monophosphate dehydrogenase in the guanosine monophosphate pathway.
Immunosuppressive agent. Suppresses cytokine-induced nitric oxide production.
Properties
assay ≥98%
EQP level Premium
Gene Information human ... IMPDH1（3614）, IMPDH2（3615）
storage temp. 2-8°C
Safety
Personal Protective Equipment Eyeshields, Faceshields, full-face particle respirator type N100 （US）, Gloves, respirator cartridge type N100 （US）, type P1 （EN143） respirator filter, type P3 （EN 143） respirator cartridges
Hazard Codes Xn
Risk Statements 61-22
Safety Statements 53-45
WGK Germany 3
RTECS MP8050000
References
reference Gummert, J.F., et al., Pharmacodynamics of immunosuppression by mycophenolic acid: inhibition of both lymphocyte proliferation and activation correlates with pharmacokinetics. J. Pharmacol. Exp. Ther. 291, 1100-1112, （1999） Abstract
Nimmesgern, E., et al., Conformational changes and stabilization of inosine 5'-monophosphate dehydrogenase associated with ligand binding and inhibition by mycophenolic acid. J. Biol. Chem. 271, 19421-19427, （1996） Abstract
Senda, M., et al., Mycophenolic acid, an inhibitor of IMP dehydrogenase that is also an immunosuppressive agent, suppresses the cytokine-induced nitric oxide production in mouse and rat vascular endothelial cells. Transplantation 60, 1143-1148, （1995） Abstract
Gummert, J.F., et. al. J. Pharmacol. Exp. Ther. 291, 1100-1112, （1999）
Nimmesgern, E., et. al. J. Biol. Chem. 271, 19421-19427, （1996）
Senda, M., et. al. Transplantation 60, 1143-1148, （1995）
Merck Merck 13,6352
Printable Reviews
Product ReviewsReview This Product
相關產品
- K0105鹽酸阿霉素/鹽酸多柔比星/鹽酸柔紅霉素/阿得里亞霉素/14-羥正定霉素/阿霉素/DOX
- K0104磺胺甲噁唑/磺胺甲惡唑/磺胺甲基異惡唑/磺胺甲基異噁唑/新明磺/新諾明/3-對氨基苯磺酰胺基-5-甲
- K0103匹馬霉素/納他霉素/那他霉素/游霉素/匹馬力星/無水奈偉拉平/Pimaricin
- K0102新生霉素
- K0046-1阿米卡星/丁胺卡那霉素/Amikacin
- K0101馬來酸羅格列酮/5-[4-[2-[N-甲基-N-（2-吡啶基）氨基]-乙氧基]芐基]噻唑烷-2,4二
- K01005-氟胞嘧啶/氟胞嘧啶/4-氨基-5-氟-2（1H）-嘧啶酮/5-Fluorocytosine
- K0099呋喃唑酮/痢特靈/3-（5-硝基糠叉氨基）-2-唑烷酮/Furazolidone
- K0098磺胺嘧啶/磺胺嘧啶鈉/2-對氨基苯磺酰胺嘧啶/磺胺噠嗪/地亞凈/Sulfadiazine
- K0097磺胺二甲基嘧啶/磺胺雙甲基嘧啶/磺胺間二甲氧嘧啶/4-氨基-N-（4，6-二甲基-2-嘧啶基）苯磺酰
